The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants .
Primary Familial Dilated Cardiomyopathy
Frequency and severity of treatment-emergent adverse events and serious adverse events. [ Time Frame: Up to 22 days ]
N/A
Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
- Has stable primary dilated cardiomyopathy due to either MYH7 or TTN variant
- Has adequate acoustic windows for echocardiography
- Maximum of 3 family members with same variant can be enrolled
- Any significant structural cardiac abnormalities on Screening transthoracic echo(s)
- A pathogenic variant implicated in DCM of another gene other than MYH7 or TTN
- Routinely scheduled outpatient intravenous (IV) infusions for heart failure (e.g., inotropes, vasodilators [e.g., nesiritide], diuretics), or routinely scheduled ultrafiltration
- Presence of protocol specified laboratory abnormalities at Screening
United States, California
University of California, San Diego Medical CenterRecruiting
La Jolla, California, United States, 92037
Contact: Maylene Alegre 858-246-2511 malegre@health.ucsd.edu
United States, District of Columbia
MedStar Georgetown University Hospital Not yet recruiting
Washington, District of Columbia, United States, 20007
Contact: Michelle Deville michelle.deville@medstar.net
United States, Florida
University of South FloridaNot yet recruiting
Tampa, Florida, United States, 33606
Contact: Nhi Tran nntran@health.usf.edu
United States, Illinois
Medical Center of Northwestern UniversityNot yet recruiting
Chicago, Illinois, United States, 60611
Contact: Hamorabi Mkrdichian hmkrdich@nm.org
United States, Massachusetts
Brigham and Women's HospitalRecruiting
Boston, Massachusetts, United States, 02115
Contact: Mary Sheehan 617-732-6237 msheehan1@bwh.harvard.edu
United States, Minnesota
Mayo Clinic - RochesterNot yet recruiting
Rochester, Minnesota, United States, 55905
Contact: Megan Peterson peterson.megan3@mayo.edu
United States, Ohio
Cleveland ClinicNot yet recruiting
Cleveland, Ohio, United States, 44195
Ohio State University Wexner Medical CenterNot yet recruiting
Columbus, Ohio, United States, 43210
United States, Pennsylvania
University of Pennsylvania - Heart and Vascular CenterNot yet recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Jessica Kim jessica.kim4@pennmedicine.upenn.edu
United States, South Carolina
Medical University of South CarolinaRecruiting
Charleston, South Carolina, United States, 29425
Contact: Ellie Cutright 843-792-2944 cutrighe@musc.edu
United States, Tennessee
The Stern Cardiovascular CenterRecruiting
Germantown, Tennessee, United States, 38138
Contact: Carye Jackman 901-448-5750 cjackman@uthsc.edu
Germany
Universitaetsklinikum HeidelbergRecruiting
Heidelberg, Germany, 69126
Contact: Sonja Tran Sonja.Tran@med.uniheidelberg.de
Universitaetsklinikum Würzburg Not yet recruiting
Würzburg, Germany, 97080
Contact: Peer Papior papior_p@ukw.de
Spain
Hospital Universitario Puerta de Hierro Majadahonda Recruiting
Majadahonda, Madrid, Spain, 28222
Contact: Ariadna Gonzalez Segovia +34 911 91 7297 ariadna.segovia@salud.madrid.org
Hospital Clinico Universitario Virgen de la Arrixaca Recruiting
El Palmar, Murcia, Spain, 28036
Contact: David Lopez +34 679 22 2025 dalopezcu@gmail.com
Complejo Hospitalario Universitario A Coruña Not yet recruiting
A Coruña, Spain, 15006
United Kingdom
St. Bartholomew's Hospital Not yet recruiting
London, United Kingdom, EC1M 6BQ
Contact: Hakam Abbass +44 020 3765 8635 hakam.abbass@nhs.net
Royal Brompton Hospital Recruiting
London, United Kingdom, UB9 6JH
Contact: Maria Teresa Pfyl +44 020 7352 8121 ext 82823 m.pfyl@rbht.nhs.uk
MyoKardia, Inc.
N/A
Contact:
Email:
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